DIABESITY: Diabetes and Obesity in Renal Disease


The global increase of obesity and type 2 diabetes (T2DM) has epidemic proportions. Worldwide, an estimated 2.16 billions subjects are overweight or obese and 382 million people have diabetes, a number that will rise to 592 million by 2035. This pandemic may portend severe consequences in Nephrology. The global increase in chronic kidney disease parallels the obesity epidemic. Obesity (starting from the overweight range) is an independent risk factors for chronic kidney disease. Also, one third of T2DM patients may develop diabetic nephropathy, which in Europe represents ~30% of patients with end-stage renal disease. Obesity, especially unhealthy obesity, and diabetes share common markers of renal disease: glomerular hyperfiltration, albuminuria, insulin resistance, chronic subclinical inflammation, alterations in lipid metabolism, among others. Thus, obesity and diabetes may represent a continuum in renal disease.

Course content

    1. Obesity as a risk factor for renal disease
    2. Renal hemodynamic alterations in obesity and diabetes
    3. The non-proteinuric pathway of GFR decline in diabetes
    4. The impact of glomerular hiperfiltration
    5. Non-alcoholic fatty liver disease and microalbuminuria
    6. Insulin Resistance, metabolic syndrome and renal disease.
    7. Inflammation in diabetic nephropathy
    8. Histological changes in diabetes and obesity
    9. Renal lipotoxicity
    10. Animal models of diabetic nephropathy
    11. Animal models of obesity-related renal disease
    12. Impact of life style interventions: exercise and calorie restriction in renal function