Description
The global increase of obesity and type 2 diabetes (T2DM) has epidemic proportions. Worldwide, an estimated 2.16 billions subjects are overweight or obese and 382 million people have diabetes, a number that will rise to 592 million by 2035. This pandemic may portend severe consequences in Nephrology. The global increase in chronic kidney disease parallels the obesity epidemic. Obesity (starting from the overweight range) is an independent risk factors for chronic kidney disease. Also, one third of T2DM patients may develop diabetic nephropathy, which in Europe represents ~30% of patients with end-stage renal disease. Obesity, especially unhealthy obesity, and diabetes share common markers of renal disease: glomerular hyperfiltration, albuminuria, insulin resistance, chronic subclinical inflammation, alterations in lipid metabolism, among others. Thus, obesity and diabetes may represent a continuum in renal disease.
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